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mPEG-Cholesterol胶束的合成、表征及其在疏水药物递送中的应用研究
发布时间:2025-07-09     作者:kx   分享到:
文章:两亲性mPEG-固醇共轭物的炼制、胶束化极其在姜黄素递送中的运用连接://dspace.nitrkl.ac.in/dspace/handle/2080/3725小说作品:普拉丹、艾斯瓦娅·帕特尔、萨比塔节选:肝癌晚期是世界各国*严重的的疾病,当时从未取得医治。广大探讨专业人员和专业家逐渐提起了那种的方案来祛除肝癌晚期,即携手*方案和对接多种类药品质粒,如脂质体、納米颗料、胶束等。在这当中,缔合物胶束成为药品递送质粒因为它的动态平衡性高些、CMC 更低、溶于性最佳、粒度小和生物体相匹配性最佳而受人注重。为了能将 PEG 基胶束自制成疏水药品质粒,自己依据缩构成犯罪制成了两亲性 mPEG-高胆固醇的食物高共轭物。安全灵活运用 1H NMR、FTIR、HRMS 光谱仪浅析对制成的缔合物外表皮上充满活力性剂采取了表现。依据紫外线可看见光和荧光法浅析了这种制成外表皮上充满活力性剂的胶束化个人行为。找到上述所说风险管理采集体制的 CMC 在微摩尔时间范围内。以姜黄素为建模 药品,探讨了安全灵活运用自制的动态平衡胶束采取疏水药品的掺进和递送。与水有机溶剂中的姜黄素相较于,姜黄素在胶束有机溶剂中的动态平衡性至关高。求算确定的药品负债错误率为 72%,可与任何胶束风险管理采集体制相比得上。依据 XRD 浅析否认了药品的掺进。灵活运用 SEM 能力浅析了外表皮上形貌。从 DSC 热浅析图也可以得知,负债姜黄素的胶束的动态平衡性过于未负债的胶束。药品宣泄曲线美否认了药品的延续宣泄,这对肝癌晚期*至关主要。还探讨了生殖细胞充满活力和*癌充满活力性。从收获的总体经济报告单看,自己自制的 mPEG-高胆固醇的食物高胶束风险管理采集体制被找到一种至关有发展潜力且高效的药品递送质粒。Cancer is a deadliest illness worldwide which is still not conquered. Several approaches have been made by various researchers and scientists to eradicate it by combined therapeutic modalities and introduction of number of drug carriers like liposomes, nanoparticles, micelles etc. Among them polymeric micelles as a drug delivery carrier has gained much more attention because of its greater stability, lower CMC, solubility, small size and biocompatibility. In an attempt to formulate PEG-based micelle as hydrophobic drug carrier, we have synthesized amphiphilic mPEG-Cholesterol conjugates by condensation method. The synthesized polymeric surfactants were characterised using 1H NMR, FTIR, HRMS spectral analysis. Micellization behaviour of these synthesized surfactants were analysed by UV-Vis and fluorescence method. The CMC of the above systems are found to be in the micro-molar range. Incorporation and delivery of hydrophobic drug using the formulated stable micelles was studied using curcumin as a model drug. The stability of curcumin was found to be very high in the micellar medium compared to the curcumin in aqueous medium. Drug loading efficiency was calculated and found to be 72% which can be comparable to the other micellar system. From the XRD analysis, the drug incorporation was confirmed. Surface morphology was analysed by using SEM technique. From the DSC thermograms, the stability of the curcumin loaded micelle was found to be higher than the unloaded micelle. Drug release profile confirmed a sustained release of drug which is vital for the cancer therapy. The cell viability and anticancer activity was also studied. From the overall results obtained, our formulated mPEG-Cholesterol micellar system found to be very promising and effective as drug delivery vehicles.

mPEG-Cholesterol

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