文章：PLGA-卵磷脂-PEG核壳纳米技术水粒子用在恶性肿瘤靶点*超链接：//www.worldscientific.com/doi/abs/10.1142/S1793984411000359著者：郑明斌， 兵兵球， 贾冬雪， 郑翠芳， 马一帆， 和 蔡林涛节选：你们曝光一个多种多功用聚乳酸-甲醇酸共聚物 (PLGA)-卵磷脂-聚乙二醇 (PEG) 核壳納米科粒 (NPs)，该納米科粒都具有脂质体和整合物納米科粒的优势之处，能作于递送放疗手术药材。该納米科粒的孔径、单单从面上正电荷和单单从面上官能团可利用各个配方法因素轻易调试，且连续性好，诸如脂质/整合物、1,2-二硬脂酰-sn-甘油-3-磷酸甲醇胺 (DSPE)-PEG- COOH /卵磷脂、DSPE-PEG- COOH /DSPE-PEG- NH 2 的質量比并且 DSPE-PEG 端基的绘制。你们将仿真模型放疗手术药材——亲水性树脂聚氨酯顺铂 (DDP) 或疏水性树脂聚氨酯 DDP 前药——封装形式于納米科粒 (NP) 中，导致提示其包封率高、固相关性佳、对高 FA 感觉理解的 MCF-7 神经元都具有活性聊天靶点甄别性能，且 FA 感觉理解量高，且神经元毒副作用较小。该类 PLGA-卵磷脂-PEG 核壳納米科粒 (NP) 已被认定书就是一种*具价值的癌症晚期靶点*药材递送納米质粒载体。AbstractWe reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG-COOH/lecithin, DSPE-PEG-COOH/DSPE-PEG-NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA–lecithin–PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.

陕西pg电子娱乐游戏app 生态学作为相关的厂品：C18-PEGn-NH2 (NH2: Amine)DSPE-PEG-GRGDSDSPE-PEG-InsulinDSPE-PEG-ChitosanDSPE-PEG-AlginateDSPE-PEG-KAA(CKAAKNK)（二硬脂酰基磷脂酰乙酸乙酯胺-聚乙二醇-*靶点蛋白酶)DPPE-mPEGDSPE-PEG-TRITC这小文章信息渠道种类杂志期刊或文章，见谅侵权行为请关系.我刪除！