文献：基于甘草酸修饰的DSPE-PEG-PEI纳米粒联合递送阿霉素和Bcl-2 siRNA的肝靶向联合*

链接：//www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00004/full

作者：Guixiang Tian，Ruiyan Pan&，Bo Zhang，Meihua Qu，LianBo Lian，Hong Jiang，Zhiqin Gao，Jingliang Wu

节选：

源于纳米级级药物剂量递送系统化的聯合物理疗法已发展壮大变成了是一种有发展前景的策咯，它根据了两种方式或各种各样**逻辑。本实验制得了由1,2-二硬脂酰-sn-甘油-3-磷酸乙酸乙酯胺-聚乙二醇-聚醚酰亚胺（DSPE-PEG-PEI）和甘草次酸突显半透明质酸原液（GA-HA）结构的肝靶点纳米级级粒（GH-DPP），采用聯合递送阿霉素（DOX）和Bcl-2 siRNA。测得了载药GH-DPP納米技术粒（siRNA/DOX/GH-DPP）的粒度分布范围、zeta电势差和状态。讲解了其对HepG2组织的组织摄食和身体之外组织致癌性。在荷瘤小鼠中评价了siRNA/DOX/GH-DPP的内部生物技术分布范围和***实际效果。结局表达，siRNA/DOX/GH-DPP納米技术粒呈近圆柱状，对HepG2组织表现形式出的用药量依赖感性的组织致癌性。与分次递送DOX或Bcl-2 siRNA的无甘草次酸共递送软件系统（siRNA/DOX/DPP）和GH-DPPnm粒对比，siRNA/DOX/GH-DPPnm粒可帮助更加多神经细胞凋亡，并展示出最高的**感觉。GH-DPPnm粒可一同将放疗用药和siRNA递运至*领域，在***中增添出巨形的发展潜力。

译文：

Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here, we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimide (DSPE-PEG-PEI) with Glycyrrhetinic acid-modified hyaluronic acid (GA-HA) for co-delivery of doxorubicin (DOX) and Bcl-2 siRNA. Particles size, zeta potential and morphology were determined for the drug-loaded GH-DPP nanoparticles (siRNA/DOX/GH-DPP). Cellular uptake and in vitro cytotoxicity were analyzed against HepG2 cells. In vivo bio-distribution and anti-tumor therapeutic effects of siRNA/DOX/GH-DPP were evaluated in H22-bearing mice. The results showed that siRNA/DOX/GH-DPP nanoparticles were nearly spherical and showed dose-dependent cytotoxicity against HepG2 cells. Compared to Glycyrrhetinic acid-free co-delivery system (siRNA/DOX/DPP) and GH-DPP nanoparticles for delivery of DOX or Bcl-2 siRNA alone, siRNA/DOX/GH-DPP nanoparticles could induce more cellular apoptosis, and showed higher anti-tumor effect. Herein GH-DPP nanoparticles could simultaneously deliver both chemotherapy drugs and siRNA into the tumor region, exhibiting great potential in anti-tumor therapy.

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