文献：基于甘草酸修饰的DSPE-PEG-PEI纳米粒联合递送阿霉素和Bcl-2 siRNA的肝靶向联合*

链接：//www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00004/full

作者：Guixiang Tian，Ruiyan Pan&，Bo Zhang，Meihua Qu，LianBo Lian，Hong Jiang，Zhiqin Gao，Jingliang Wu

节选：

来源于納米药递送控制系统的综合治疗已发展方向当上另外一种有行业前景的手段，它组合了四种或三种**体系。本实验备制了由1,2-二硬脂酰-sn-甘油-3-磷酸工业乙醇胺-聚乙二醇-聚醚酰亚胺（DSPE-PEG-PEI）和甘草次酸突显半透质酸（GA-HA）成分的肝靶向疗法納米粒（GH-DPP），用作综合递送阿霉素（DOX）和Bcl-2 siRNA。检测法了载药GH-DPP奈米粒（siRNA/DOX/GH-DPP）的粒级、zeta电极电位和特性。深入分析了其对HepG2受损体组织细胞系核的受损体组织细胞系核摄入和身体之外受损体组织细胞系核毒素。在荷瘤小鼠中风险评估了siRNA/DOX/GH-DPP的身体内生物体布局和***郊果。結果表面，siRNA/DOX/GH-DPP奈米粒呈近圆球形，对HepG2受损体组织细胞系核体现出标准容量依耐性的受损体组织细胞系核毒素。与重新递送DOX或Bcl-2 siRNA的无甘草次酸共递送装置（siRNA/DOX/DPP）和GH-DPP奈米粒相对来说，siRNA/DOX/GH-DPP奈米粒也能引发大量体细胞凋亡，并表現出高的**感觉。GH-DPP奈米粒也能时将肺癌晚期化疗治疗药物和siRNA递送进*地域，在***中凸显出比较大的潜力股。

译文：

Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here, we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimide (DSPE-PEG-PEI) with Glycyrrhetinic acid-modified hyaluronic acid (GA-HA) for co-delivery of doxorubicin (DOX) and Bcl-2 siRNA. Particles size, zeta potential and morphology were determined for the drug-loaded GH-DPP nanoparticles (siRNA/DOX/GH-DPP). Cellular uptake and in vitro cytotoxicity were analyzed against HepG2 cells. In vivo bio-distribution and anti-tumor therapeutic effects of siRNA/DOX/GH-DPP were evaluated in H22-bearing mice. The results showed that siRNA/DOX/GH-DPP nanoparticles were nearly spherical and showed dose-dependent cytotoxicity against HepG2 cells. Compared to Glycyrrhetinic acid-free co-delivery system (siRNA/DOX/DPP) and GH-DPP nanoparticles for delivery of DOX or Bcl-2 siRNA alone, siRNA/DOX/GH-DPP nanoparticles could induce more cellular apoptosis, and showed higher anti-tumor effect. Herein GH-DPP nanoparticles could simultaneously deliver both chemotherapy drugs and siRNA into the tumor region, exhibiting great potential in anti-tumor therapy.

成都pg电子娱乐游戏app 生态学给出相应食品：Cy5-PEG-DPPEPeptides PEG PLADSPE-PEG-SP94iRGD-PEG-DSPEPTP-PEG-COOHAngiopep-2-PEG-N3DMPE-PEG-CY3cRGD-PEG-PLGA

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