文献资料：适用原子结构力谱法鉴定束缚调教1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱膜的杨氏模量链接转换：//pubs.acs.org/doi/abs/10.1021/jp505451h小说作者：王曦，罗伯特·N·桑德森‡雷吉娜·拉根英文论文：将由盐溶液浓硫酸浓度在0 mol %至24 mol %当中的1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱 (POPC) 和其他盐溶液浓硫酸浓度的1,2-二硬脂酰-sn-甘油-3-磷酸无水乙醇胺-N-聚乙二醇-2000- N- [3-(2-吡啶基二硫代)丙酸酯] (DSPE-PEG-PDP) 包含的一层囊泡安装在原子团核级铺布的网站模板脱离金 (TS Au) 外层。用原子团核力高倍显微镜 (AFM) 对保护液相应得束搏脂质多层膜 (tLBM) 实施力谱讲解，出具了更多机回应随束搏原子核 DSPE-PEG-PDP 盐溶液浓硫酸浓度变化规律的数据信息。杨氏模量根据运用近几天更改的 Sneddon 模式化折线拟合力-压印折线来设定，该模式化调节了来于评论基本材料的重大贡献。在密度计算公式值下，杨氏模量远低于能够的 POPC LBM（即直接的建在固态物底材上）。模量的降低了归因于膜出入性的扩大，如果根据掺量 DSPE-PEG-PDP 枷锁基团，tLBM 和固态物底材两者的藕合增多了。从法测的杨氏模量值所知，密度值少于 6 mol % 时，PEG 链构象决定了 tLBM 的 刚性轨道。AFM 力谱参数研究表达，聚乙二醇 (PEG) 磨菇到毛刷的变化时有发生在 6 mol % 旁边，这引发 tLBM 在更加高的 DSPE-PEG-PDP 密度值下先回软，然而就变硬，这与变化关干。当 DSPE-PEG-PDP 密度值扩大到 24 mol % 时，AFM 形貌和杨氏模量因此与另外一只个相变向关； AFM 形貌图案与双层线路盘空间结构相符，这之中 DSPE-PEG-PDP 屏蔽在盘的边部。

AbstractUnilamellar vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with varying 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-poly(ethylene glycol)-2000-N-[3-(2-pyridyldithio) propionate] (DSPE-PEG-PDP) concentration between 0 mol % and 24 mol % were assembled on atomically flat template-stripped gold (TS Au) surfaces. Force spectroscopy, using an atomic force microscope (AFM), of the resulting tethered lipid bilayer membranes (tLBMs) in buffer provided information regarding mechanical response as a function of tethering molecule, DSPE-PEG-PDP, concentration. Young’s modulus was determined by fitting the force–indentation curve with a recently modified Sneddon model that corrects for contributions from the substrate underneath. At low concentrations, Young’s modulus is lower than that of a supported POPC LBM, i.e., directly sitting on a solid substrate. The decrease in modulus is attributed to increased membrane fluidity as coupling between the tLBM and solid substrate is reduced by the incorporation of DSPE-PEG-PDP tethering groups. From the determined Young’s modulus values, the PEG chain conformation is found to dominate tLBM rigidity at concentrations above 6 mol %. Analysis of AFM force spectroscopy data indicates that the poly(ethylene glycol) (PEG) mushroom to brush transition occurs near 6 mol %, and this leads to first softening and then abrupt stiffening of tLBMs at higher DSPE-PEG-PDP concentration associated with the transition. When DSPE-PEG-PDP concentration is increased to 24 mol %, AFM topography and Young’s modulus appear correlated with another phase transition; AFM topography images are consistent with a bilayer disk structure with DSPE-PEG-PDP segregated at the rim of the disk.绵阳pg电子娱乐游戏app 生态学出示相关联服务：DSPE-PEG-Cy5.5DSPE-PEG-Cy7DSPE-PEG-NBDDSPE-PEG-TRITCDSPE-PEG-ComarinDSPE-PEG-ICGDSPE-PEG-PyreneDSPE-PEG-Ce6DSPE-PEG-Cy3大于文章知识知识来源于以及论文期刊或文献综述，假如侵犯肖像权请连接我国删了！