参考文献：线粒体、溶酶体和内质网：什么样是光疗的绝佳靶点？地址：//www.sciencedirect.com/science/article/abs/pii/S0168365922006320笔者：李艳红 ，贾浩然 ，王洪 银，华先武 ，鲍彦文 ，吴福 根节选：前言光的驱原因保健法(PDT) 有的是种厉害的肠癌诊治具体做法，其亚肿瘤人体人体上皮生殖细胞核核功能位点的精确度世界保持对其有用性至关非常重要。但，正确有点与众不一肿瘤人体人体上皮生殖细胞核核器靶点药物 PDT 做法的的作用存在挑衅性，正是因为太难查到一两个从单一的系统就就可以保持对与众不一肿瘤人体人体上皮生殖细胞核核器的直接靶点药物性、可分割的用时窗和类似的的紧密整合量。这里，我门将二氢卟酚 e6 (Ce6) 与 1,2-二硬脂酰-sn-甘油-3-磷酸甲醇胺-N- [氨基(聚乙二醇)-5000]（铵盐）（DSPE-PEG 5000 -NH 2）偶联取到 DSPE-PEG-Ce6，其在肿瘤人体人体上皮生殖细胞核核内化后就可以从线粒体迁出到溶酶体，然后到内质网 (ER)。归功于DSPE-PEG-Ce6亚肿瘤人体人体上皮生殖细胞核核占比的日常共享性、其与肿瘤人体人体上皮生殖细胞核核器紧密整合量的可调节性，我门正确地确立了该大分子的光的驱原因诊治（PDT）的作用按序，即线粒体 > 内质网 > 溶酶体。本研究探讨提出了了一大两个期望的整治系统，需用于正确估评单一肿瘤人体人体上皮生殖细胞核核器靶点药物的光的驱原因诊治（PDT）的作用，并可能有利于在未来有用光的驱原因诊治攻略的进展。AbstractPhotodynamic therapy (PDT) is a robust cancer treatment modality, and the precise spatiotemporal control of its subcellular action site is crucial for its effectiveness. However, accurate comparison of the efficacy of different organelle-targeted PDT approaches is challenging since it is difficult to find a single system that can achieve separate targeting of different organelles with separable time windows and similar binding amounts. Herein, we conjugated chlorin e6 (Ce6) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (ammonium salt) (DSPE-PEG5000-NH2) to afford DSPE-PEG-Ce6, which could migrate from mitochondrion to lysosome and ultimately to endoplasmic reticulum (ER) after cellular internalization. Benefiting from the dynamic subcellular distribution of DSPE-PEG-Ce6 with tunable organelle-binding amounts, we accurately determined the PDT efficacy order of the molecule, i.e., mitochondrion > ER > lysosome. This work proposes an ideal model system for accurately evaluating the specific organelle-targeted PDT efficacy and may promote the future development of effective PDT strategies.

石家庄pg电子娱乐游戏app 动物供应各种相关产品的：SP94-PEG-DSPET7(HAIYPRH)-PEG-DSPEOctreotide-PEG-DSPEYIGSR-PEG-DSPEAPRPG-PEG-DSPENGR-PEG-DSPE之内文章玩法玩法由来当下杂志或论文参考文献，如果有侵犯肖像权请取得联系他们卸载！