参考文献：PLGA-卵磷脂-PEG核壳納米激光束主要用于癌症晚期靶向疗法*超链接：//www.worldscientific.com/doi/abs/10.1142/S1793984411000359小编：鲜丽， 里克·奥克塔维安蒂·托伊普， 陶鹏， 和 林诗琳结语：我大家有关资料一堆种多的功能聚乳酸-无水乙酸乙酯酸共聚物 (PLGA)-卵磷脂-聚乙二醇 (PEG) 核壳nm激光束 (NPs)，该nm激光束集于一身脂质体和配位高聚物nm激光束的优势，可以选择于递送手术中成药。该nm激光束的比表明积、表明电势和表明官能团可经过各种各样的方法性能指标不累可以调节，且重新性好，举例子脂质/配位高聚物、1,2-二硬脂酰-sn-甘油-3-磷酸无水乙酸乙酯胺 (DSPE)-PEG- COOH /卵磷脂、DSPE-PEG- COOH /DSPE-PEG- NH 2 的重量比各类 DSPE-PEG 端基的呈现。我大家将仿真模型手术中成药——亲水溶性顺铂 (DDP) 或疏水溶性 DDP 前药——封装形式于nm小粒肥料 (NP) 中，然而表示其包封率高、动态平衡性佳、对高 FA 多巴胺感觉把你想表达爱出来的 MCF-7 内部有特情人靶向疗法疗法认别学习能力，且 FA 多巴胺感觉把你想表达爱出来量高，且内部致毒较小。这种 PLGA-卵磷脂-PEG 核壳nm小粒肥料 (NP) 已被证明材料是种*具竟争力的肺癌靶向疗法疗法*中成药递送nm形式。Abstract：Protein cages have been widely investigated as molecular drug carrier. E2 protein from Bacillus stearothermophillus forms a dodecahedral cage structure of approximately 24 nm in diameter. To formulate a sustainable release profile, E2 protein was further encapsulated into poly(lactide-co-glycolide) (PLGA) microparticles to form a composite structure using water-in-oil-in-water (W/O/W) double emulsion method. The influence of fabrication parameters on microparticle morphology and E2 protein release profile were investigated. The microparticle size increased when the stirring speed of the second emulsification decreased. Decrease in the volume of external aqueous phase led to the reduction of microparticle size without affecting its porosity. The higher ionic concentration of external aqueous phase in the presence of surfactant resulted in microparticles with closed pores on surface. Increase in polymer concentration also led to the formation of less porous microparticles. The E2 protein was not dissociated upon encapsulation into PLGA microparticles based on the unchanged particle size of E2 protein. E2 protein release was studied in phosphate-buffered saline solution at 37°C. The initial burst and release rate were lowered as the surfactant concentration in external water phase during the fabrication process was increased from 0.1% to 1% (w/v). After 14-day incubation, no observable polymer degradation was found while the surface of microparticles appeared to be smoother than before incubation.

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