学术论文：Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer参考文献链接搜索：//www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.575365/full小说作者：Jun Shao&#x;Jun Shao1†Xiaoming Zheng&#x;Xiaoming Zheng1†Longbao FengLongbao Feng2Tianyun LanTianyun Lan3Dongbing DingDongbing Ding1Zikai CaiZikai Cai1Xudong ZhuXudong Zhu1Rongpu LiangRongpu Liang1Bo Wei*Bo Wei1*

As shown in Scheme 1, first, DSPE-PEG-RGD was obtained based on the Michael addition reaction between RGD peptide and DSPE-PEG-Mal. Second, the NIR agent ICG was encapsulated by the DSPE-PEG-RGD matrix via the self-assembly method. DSPE-PEG-Mal is an amphiphilic polymer. PEG serves as a hydrophilic unit to form the shell while DSPE is a hydrophobic unit to form the hydrophobic cavity with ICG in the core. The synthesis and Characteristics of DSPE-PEG-RGD@ICG were analyzed, including 1H NMR spectroscopy, transmission electron microscope (TEM), and so on. Then, the cellular uptake and biocompatibility were assessed. In addition, by using an optical imaging system, we observed the biodistribution and improved accumulation of DSPE-PEG-RGD@ICG in the tumor. The results of this study may provide a promising nanocarrier to realize the future clinical application of optical molecular imaging in early diagnosis and accurate resection of GC.

率先，为RGD肽和DSPE-PEG-Mal范围内的Michael加强不起作用才能得到DSPE-PEG-RGD。另外，实现自折装技术超过红外化学试剂ICG包封在DSPE-PEG-R GD机质中。DSPE-PEG-Mal是一个种两亲性缔合物。PEG算作亲水模快测试组成机壳，而DSPE算作疏水模快测试组成疏水腔，ICG坐落在关键。提炼极其形态DSPE-PEG-RGD@ICG可以通过1H NMR光谱图、散射网上光学显微镜（TEM）等对其进行研究，那么分析神经元摄取量和怪物混溶性。不但，借助运行电子光电技术三维显像设计，我门关注了DSPE-PEG-RGD@ICG在淋巴肿瘤中。本探究的最终几率为构建电子光电技术氧分子三维显像在GC尽早检验和最准去除中的未来十年临床治疗利用展示 有发展方向的奈米媒介。

涉及到推建服务：TH-PEG-DSPER6H4-PEG-DSPEMPG-PEG-DSPEGE11-PEG-DSPEPTP-PEG-DSPESP94-PEG-DSPET7(HAIYPRH)-PEG-DSPEOctreotide-PEG-DSPEYIGSR-PEG-DSPEAPRPG-PEG-DSPENGR-PEG-DSPE之上好的文章项目的来源当下中文核心期刊或文献资料，如不侵权商标请认识我们都删去！