期刊论文：Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer论文参考文献链接代码：//www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.575365/full小说作者：Jun Shao&#x;Jun Shao1†Xiaoming Zheng&#x;Xiaoming Zheng1†Longbao FengLongbao Feng2Tianyun LanTianyun Lan3Dongbing DingDongbing Ding1Zikai CaiZikai Cai1Xudong ZhuXudong Zhu1Rongpu LiangRongpu Liang1Bo Wei*Bo Wei1*

As shown in Scheme 1, first, DSPE-PEG-RGD was obtained based on the Michael addition reaction between RGD peptide and DSPE-PEG-Mal. Second, the NIR agent ICG was encapsulated by the DSPE-PEG-RGD matrix via the self-assembly method. DSPE-PEG-Mal is an amphiphilic polymer. PEG serves as a hydrophilic unit to form the shell while DSPE is a hydrophobic unit to form the hydrophobic cavity with ICG in the core. The synthesis and Characteristics of DSPE-PEG-RGD@ICG were analyzed, including 1H NMR spectroscopy, transmission electron microscope (TEM), and so on. Then, the cellular uptake and biocompatibility were assessed. In addition, by using an optical imaging system, we observed the biodistribution and improved accumulation of DSPE-PEG-RGD@ICG in the tumor. The results of this study may provide a promising nanocarrier to realize the future clinical application of optical molecular imaging in early diagnosis and accurate resection of GC.

第一，立于RGD肽和DSPE-PEG-Mal之間的Michael加持表现获取DSPE-PEG-RGD。二、，完成自组装流水线策略一过红外免疫试剂ICG包封在DSPE-PEG-R GD机质中。DSPE-PEG-Mal一种两亲性缩聚物。PEG充当亲水模快尺寸建成外层，而DSPE充当疏水模快尺寸建成疏水腔，ICG座落主要。结合极其形态DSPE-PEG-RGD@ICG借助1H NMR光谱仪、散射电商体视显微镜（TEM）等完成概述，后来测评细胞系摄取量和生物体相匹配性。除此以外，进行安全使用光电技术成相系統，公司观察动物了DSPE-PEG-RGD@ICG在恶性肿瘤中。本论述的结杲能够为进行光电技术分子式成相在GC中期诊断仪和精确性做手术中的市场前景诊疗用途给出有市场前景的微米承载。

有关比较适合设备：TH-PEG-DSPER6H4-PEG-DSPEMPG-PEG-DSPEGE11-PEG-DSPEPTP-PEG-DSPESP94-PEG-DSPET7(HAIYPRH)-PEG-DSPEOctreotide-PEG-DSPEYIGSR-PEG-DSPEAPRPG-PEG-DSPENGR-PEG-DSPE综上所述新闻稿件网站内容来历常见中文核心期刊或文献资料，如果有侵犯肖像权请取得联系咱们删了！