论文：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy文章联接：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205作著：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su绪论：AimWe designed acid-labile methotrexate (MTX) targeting prodrug self-assembling nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi-chemotherapeutic drugs and combination cancer therapy.MethodsA dual-acting MTX, acting as both an anticancer drug and as a tumor-targeting ligand, was coupled to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[aldehyde(polyethylene glycol)-2000] via Schiff’s base reaction. The synthesized prodrug conjugate (DSPE-PEG-Imine-MTX) could be self-assembled into micellar nanoparticles (MTX-Imine-M) in aqueous solution, which encapsulated CUR into their core by hydrophobic interactions (MTX-Imine-M-CUR).

的结果准备的MTX-Imine-M-CUR納米小粒由內部疏水DSPE/CUR关键和外表亲水双羟基聚乙二醇（PEG）底壳包含，底壳有自靶点MTX前药冠。1,2-二硬脂酰-sn-甘油-3-磷酸乙酰胺-N-[醛（聚乙二醇）-2000]和MTX两者的亚胺接连体作为一个动态数据共价键，足够了强，即是在呈强酸pH下尽快裂解，在生理上pH下也能够始终维持全面。MTX-imine-M-CUR行借助DHA蛋白激酶介导的内吞用选性有效率地将MTX和CUR商品编码到癌病细胞核中，马上又借助内体/溶酶体的呈强酸尽快宣泄CUR和特异性表现形式的MTX。与此同时，MTX-Imine-M-CUR在身体之外和胃中的*癌渗透性显然大于pH不敏感性的载荷CUR的DSPE-PEGAmide-MTX制做納米技术科粒剂（MTX-Amide-M-CUR）、载荷CUR（M-CUR）的MTX非偶联DSPE-PEG制做胶束納米技术科粒剂、二者游走药剂量的组合起来和一个游走药剂量。相关联推薦：TAT-PEG-DSPECy3-iRGD-PEG-DSPEFITC-iRGD-PEG-DSPER8-PEG-DSPEAngiopep-2-PEG-DSPEFITC-Angiopep-2-PEG-DSPETH-PEG-DSPER6H4-PEG-DSPE往上短文玩法来源地各项杂志或学术论文，如不抄袭请认识当我们去除！