资料：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy文献综述联结：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205编辑：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su论文摘要：AimWe designed acid-labile methotrexate (MTX) targeting prodrug self-assembling nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi-chemotherapeutic drugs and combination cancer therapy.MethodsA dual-acting MTX, acting as both an anticancer drug and as a tumor-targeting ligand, was coupled to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[aldehyde(polyethylene glycol)-2000] via Schiff’s base reaction. The synthesized prodrug conjugate (DSPE-PEG-Imine-MTX) could be self-assembled into micellar nanoparticles (MTX-Imine-M) in aqueous solution, which encapsulated CUR into their core by hydrophobic interactions (MTX-Imine-M-CUR).

结果显示提纯的MTX-Imine-M-CUR奈米科粒由内部的疏水性聚氨酯树脂DSPE/CUR重点和对外部亲水性聚氨酯树脂双羟基聚乙二醇（PEG）塑料壳組成，塑料壳更具自靶点MTX前药冠。1,2-二硬脂酰-sn-甘油-3-磷酸乙酰胺-N-[醛（聚乙二醇）-2000]和MTX之前的亚胺连到体作为一个动态信息共价键，会强，既然在含咸性pH下更快裂解，在顺利pH下还会增加完整详细。MTX-imine-M-CUR会能够孕妇叶酸多巴胺受体介导的内吞的功效确定性行之有效地将MTX和CUR商品编号到肺癌上皮细胞中，继而能够内体/溶酶体的含咸性更快释放出来CUR和灵活性模式的MTX。不仅，MTX-Imine-M-CUR在身体和身体的*癌活性酶类显然少于pH不明感的装载CUR的DSPE-PEGAmide-MTX装配nm顆粒剂（MTX-Amide-M-CUR）、装载CUR（M-CUR）的MTX非偶联DSPE-PEG装配胶束nm顆粒剂、多种自由口服药的组合公式和单一个自由口服药。有关推送：TAT-PEG-DSPECy3-iRGD-PEG-DSPEFITC-iRGD-PEG-DSPER8-PEG-DSPEAngiopep-2-PEG-DSPEFITC-Angiopep-2-PEG-DSPETH-PEG-DSPER6H4-PEG-DSPE上面原创文章信息源于各样论文期刊或学术论文，如遇商标侵权请沟通让我们删除图片！