DSPE-PEG-FA修饰纳米颗粒用于增强肿瘤细胞摄取与核定位释放
DSPE-PEG-FA体现nm颗粒物广泛用于资料*组织摄取量与核定表位保持联结://pubs.acs.org/doi/abs/10.1021/acsami.5b05038小说作家:杨丽,林金艳,杨吉祥,李彦修,吴世超,玉皇,叶社芳,谢丽娅,戴理宗,侯真庆文献综述:融入丝裂霉素C (MMC)–磷脂组合物可的提升药品包封率并缩减药品早点降低甚至DSPE-PEG-DHA (DSPE-PEG-FA) 可作于特喜欢的人靶向疗法治疗*的资源优势,小编通讯报道新一种简洁的一锅自拆装自驾路线来制法乘载MMC–磷脂组合物的DSPE-PEG基納米颗料 (MP-PEG-FA NPs)。共凝焦影像和普鲁士蓝染色神经元术均体现了,在神经元摄入和神经元内药品递送后,MMC地域分布到神经元核中。更至关重要的是,全身性给药的MP-PEG-FA NPs可新增HeLa*裸鼠的血长时间性和强化的*蓄积。本探究介紹新一种简洁很好的的方案来制定应用场景*癌药品–磷脂组合物的靶向疗法治疗药品递送系统的,以满足持续保持/控制的药品降低。译文翻译:Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.



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