DSPE-PEG-FA修饰纳米颗粒用于增强肿瘤细胞摄取与核定位释放
DSPE-PEG-FA呈现納米颗料中用强化*血细胞摄食与核定表位脱离连接://pubs.acs.org/doi/abs/10.1021/acsami.5b05038小说作品:杨丽,林金艳,杨瑞祥,李彦修,吴世超,玉皇,叶社芳,谢丽娅,戴理宗,侯真庆内容提要:组合丝裂霉素C (MMC)–磷脂和好物可升高制剂包封率并极大减少制剂太晚发出并且DSPE-PEG-孕妇叶酸 (DSPE-PEG-FA) 都可以于特异形靶点疗法*的优缺点,我们的报导没事种比较简单化的一锅自装设路线图来制取放有MMC–磷脂和好物的DSPE-PEG基納米颗料 (MP-PEG-FA NPs)。共准确把握影像和流式体上皮受损细胞系术体上皮受损细胞系术均表面,在体上皮受损细胞系摄食和体上皮受损细胞系内制剂递送后,MMC区域划分到体上皮受损细胞系核中。更最重要的是,混身给药的MP-PEG-FA NPs可提高HeLa*裸鼠的血渍经久耐用性和开展的*蓄积。本研究方案介召没事种比较简单化有郊的战略来定制来源于*癌制剂–磷脂和好物的靶点疗法制剂递送软件系统,以完成一直/把握的制剂发出。译文翻译:Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.