论文资料：Novel DSPE-PEG-Cholic Acid-Modified Liposomes with Hepatic Targeting Properties Improve the Anti-Tumor Efficacy of Oral Doxorubicin Hydrochloride for Liver Tumor-Bearing MiceDOI: 诗人: Li, Ying; Yang, Dandan; Zhang, Yun; Zhu, Chunyan英文论文：DSPE-PEG-cholic acid-modified liposomes (functional liposomes) with hepatic targeting via oral administration properties were explored for the loading of DOX·HCl. DSPE-PEG-cholic acid-modified DOX·HCl liposomes (functional DOX·HCl liposomes) were developed as an oral therapy that targets hepatic cancers. Subsequently, the effects of liposome formulations were investigated using in vitro HepG2 cell uptake assays, in vivo intestine distribution and targeting efficacy experiments in orthotopic HepG2 nude mice xenograft tumors and subcutaneous H22 mice xenograft tumors. Functional DOX·HCl liposomes of approximately 100 nm in diameter significantly increased the intracellular uptake of DOX·HCl, revealing strong inhibitory effects on HepG2 cells. Moreover, orally administered functional DOX·HCl liposomes demonstrated stronger antitumor efficacy than DOX·HCl and DOX·HCl liposomes in orthotopic HepG2 xenograft mice, but similar antitumor efficacy to DOX·HCl liposomes in subcutaneous H22 xenograft mice. In further analyses, cardiac and kidney toxicities were significantly reduced after orally administering functional DOX·HCl liposome formulations. The present data indicate that the oral administration of functional DOX·HCl liposomes increases hepatic targeting, provides superior efficacy of suppressing xenograft tumor, and overcomes limited cardiac and kidney toxicity.

摸索了经由内服给药具有着肝靶点药物性的DSPE-PEG-胆酸突显脂质体（能力模块性脂质体）负债DOX·HCl的性能特点。设计规划了DSPE-PEG-胆酸突显的DOX·HCl脂质体（能力模块性DOX·HCl-脂质体）对于靶点药物肝癌的内服方式。随即，使用的身体之外HepG2内部摄取量量耐压、人体肠内规划和原位HepG2裸鼠异种试管移植后肺部癌肿和肉里H22小鼠异种试管移植后肺部癌肿的靶点效用实验性深入分析了脂质管理体制剂的影响力。外径约为100 nm的功能表性DOX·HCl脂质体相关性提高了DOX·HCI的内部内摄取量量，对HepG2内部屏幕上显示出强列的限设计用。另外，在原位HepG2异种种植物小鼠中，服食实用多技能性DOX·HCl脂质体比DOX·HCI和DOX·HCl脂质体兼具更强的抗良性淋巴癌肿效应，但在皮下组织H22异种种植物鼠中，其抗良性淋巴癌肿效应与DOX·稀盐酸脂质体类似。在更进一步骤的定量分析中，服食实用多技能性DOX·HCl脂质体制机制剂后，肝脏和肾脏致毒相关系数降低。近些年的参数取决于，服食实用多技能性DOX·HCl脂质体可增高肝靶点性，具备调控异种种植物良性淋巴癌肿的优秀药效，并摆脱有限公司的肝脏和肾脏致毒。对应比较适合：DSPE-PEG-FITCDSPE-PEG-FolateDSPE-PEG-IADSPE-PEG-MalDSPE-PEG-NH2DSPE-PEG-NHSDSPE-PEG-OHDSPE-PEG-propargylDSPE-PEG-AlkyneDSPE-PEG-Rhodamine邻接权宣称：本渠道据各种相关的技术期刊杂志文献综述、英语教材各类企业网站编译归类的的内容，仅采用对各种相关的物理学作品集的说明、点评各类课上上课或物理学深入分析。告之知识产权侵权，请练习.我移除。